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About Osteoarthritis

by Arthritis Foundation

Osteoarthritis is the leading cause of disability in the general population of the United States.1,2 The Centers for Disease Control confirms that approximately 1 in 3 adults with arthritis reported limitation in their usual activities. Arthritis of the knee alone afflicts more than 4 million people, and research shows 14 percent of individuals interviewed within the age group of 40 to 79 described knee pain with disability on most days of the previous month.3 Because of the increase in life expectancy within most societies of the western world, the high prevalence of OA is expected to increase further in upcoming years. For example, the number of first-time total knee replacements (TKR) is expected to skyrocket 673 percent to 3.48 billion by 2030.5




Osteoarthritis is also associated with extensive direct and indirect costs and represents a considerable burden for the healthcare system and society as a whole.

In the United States, the cost of medical care and lost productivity is estimated at $86.2 billion. In the year 2000, hospital costs in the United States for TKR surgery topped $11 billion.5,6 Beyond this condition’s economic burden, arthritis affects the quality of life for those afflicted and is associated with disabling one’s activities of daily living. Physical therapy is among the treatment options for people who suffer from osteoarthritis and intends to prevent physical impairment and restore functional ability through the use of exercise, physical modalities, and patient education. Current evidence supports the effectiveness and safety of moderate- to high-intensity aerobic and strengthening exercises for osteoarthritis. It is important to note that participation in recreational activities does not replace the need for therapeutic exercises.

It’s in the Joints

OA is a degenerative condition that affects subchondral bone, joint synovium, tendons, ligaments, muscles, and particularly large weight-bearing joints. The affected cartilage initially develops small tears at the articular surface, which eventually results in larger tears. The cartilage eventually fragments off into joints with cartilage-forming cells called chondrocytes replicating in an attempt to keep up with the cartilage loss. Over time, these cells eventually are unable to produce at the rate of degeneration and the underlying bone becomes exposed.


Risk factors associated with knee OA are genetic predisposition, obesity (i.e., body mass index > 30 kg/m2), advancing age, and physically demanding occupations.3 OA is particularly common in older patients, but can occur in the younger population either through genetics or, more commonly, because of previous joint trauma. Symptoms of OA include pain during and/or after use, joint stiffness, swelling, crepitus, and loss of motion.

Several methods exist that can help diagnose knee and other forms of OA. The Kellgren and Lawrence System is the most universally accepted method for classifying degrees of OA and is based on radiographic findings.7 The Kellgren and Lawrence System uses four radiographic features: joint space narrowing, osteophytes, subchondral sclerosis, and subchondral cysts. Another method of staging called the Outerbridge method classifies articular cartilage damage based on the arthroscopic findings in patients affected with OA.

The four grades are:

Grade I — Softening and swelling
Grade II — Fragmentation and fissuring < 0.5 inches
Grade III — Fragmentation and fissuring > 0.5 inches
Grade IV — Erosion down to the subchondral bone

The American College of Rheumatology recommends a combination of history, physical examination, and laboratory tests as the three methods to help diagnose OA of the knee.8

However, simple clinical criteria diagnose OA of the knee with a sensitivity of 89 percent and a specificity of 88 percent.

Criteria to Diagnose Knee Osteoarthritis

Knee pain, < 38 years, bony enlargement
Knee pain, > 39 years, bony enlargement, morning stiffness > 30 minutes
Knee pain, bony enlargement, morning stiffness > 30 minutes, crepitus with active motion
Knee pain, >38 years, bony enlargement, morning stiffness > 30 minutes, crepitus with active motion

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About Medical Management of OA
by: Arthritis Foundation

Medical Management

Physicians may use acetaminophen (Tylenol) as a first-line therapy for patients with mild OA symptoms who do not have contraindications to this medication.10 However, for people with moderate to severe OA, or for those with mild OA symptoms who do not respond to acetaminophen, nonsteroidal anti-inflammatory medications are commonly prescribed.10

NSAIDs, while useful in the management of OA, are not without potentially dangerous adverse effects. NSAIDs can cause kidney toxicity by causing reduced blood flow and sodium retention. This can result in renal failure in addition to hypertension, edema, and congestive heart failure.10 NSAIDs can also affect the stomach, resulting in gastritis and gastric ulcers in patients seen by physical therapists. Additionally, it is not uncommon for people, including outpatient physical therapy patients, to mix over-the-counter NSAIDs with prescription medication, compounding the risk for GI complications.11,12

Finally, NSAIDs can block the antithrombotic effect of aspirin, interfering with the therapeutic effects of aspirin therapy taken by patients for the management of cardiovascular disease.

Physical therapists can screen for potential medication mishaps and related patient concerns, which should be relayed to the patient’s physician. Pharmacologic management of OA, while an important component in the overall management of OA, is a complex issue and requires diligent medical monitoring to ensure patient safety and effective outcomes.

Intra-articular steroid injections may provide pain relief and have an anti-inflammatory effect on the affected joint. Options for joint injections generally consist of glucocorticoids (i.e., steroids) or hyaluronic acid (HA) products.

Steroid injections, such as triamcinalone hexacetonide (Aristospan), represent a short-term option for patients with OA of the knee and result in reduction of pain as soon as one week after injection with benefits lasting potentially for up to a month.13 However, such injections carry the potential for complications that range from mild synovitis to infection, tendon weakening or rupture, and nerve damage.14 As a result, controversial evidence exists regarding frequent administration and usually no more than three injections are recommended per year in any one osteoarthritic joint.

HA is a vital component of both articular cartilage and synovial fluid. Healthy articular cartilage has a balance of extracellular matrix turnover — matrix that is broken down by the body and replaced by new matrix. When an imbalance occurs so that the matrix degradation is greater than matrix production, OA begins its destructive process. The intra-articular injection of HA products — viscosupplementation — is meant to improve the health of affected joints by enhancing the viscoelastic nature (shock absorption and lubrication) of synovial fluid and, in the long term, affect the return of metabolic homeostasis of the joint.15



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